货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S82060-5mg	≥95%	￥1800.00 S82060-5mg ￥1800.00 3-5天	0 货期：3-5天	-	-	-	-
S82060-10mg	≥95%	￥2680.00 S82060-10mg ￥2680.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitor

靶点：

Others

体外研究：

GDC-0834 inhibited BTK (IC50s: 5.9 and 6.4 nM in biochemical and cellular assays) and (IC50s: 1.1 and 5.6 μM in mouse and rat)

体内研究：

Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology. GDC-0834 exhibited low clearance in PXB chimeric mice with humanized liver. GDC-0834 plasma concentrations in humans were below the limit of quantitation (<1 ng/ml) in most samples from the cohorts dosed orally at 35 and 105 mg

参考文献：

1. Liu L, et al. Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor. Drug Metab Dispos. 2011 Oct;39(10):1840-9. 2. Liu L, et al. Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy. J Pharmacol Exp Ther. 2011 Jul;338(1):154-63.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.676 ml	8.379 ml	16.758 ml
5 mM	0.335 ml	1.676 ml	3.352 ml
10 mM	0.168 ml	0.838 ml	1.676 ml
50 mM	0.034 ml	0.168 ml	0.335 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

GDC-0834 (Racemate)