| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S82070-2mg |
99.7% | ￥238.00 | 5 | - | - | - |
|
S82070-5mg |
99.7% | ￥292.40 | 4 | - | - | - |
|
S82070-10mg |
99.7% | ￥530.40 | 4 | - | - | - |
|
S82070-25mg |
99.7% | ￥1258.00 | 4 | - | - | - |
|
S82070-50mg |
≥98% | ￥2000.00 | 货期：2-3天 | - | - | - |
|
S82070-100mg |
≥98% | ￥3200.00 | 货期：2-3天 | - | - | - |
|
VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia
| 产品描述： | VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia | ||||||||||||||||||||
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| 靶点： | IC50: 477 nM (M1);AChR | ||||||||||||||||||||
| 体内研究： | VU0357017 (1-10 mg/kg, i.p.) reverses scopolamine-induced disruption of the contextual fear conditioning response | ||||||||||||||||||||
| 参考文献： | 1. Digby GJ, et al. Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36. 2. Lebois EP, et al. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system. ACS Chem Neurosci. 2010;1(2):104-121. 3. Digby GJ, et al. Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. J Neurosci. 2012 Jun 20;32(25):8532-44. | ||||||||||||||||||||
| 溶解性： | H2O : 33.33 mg/mL (90.11 mM; Need ultrasonic) DMSO : 25 mg/mL (67.59 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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