货号	规格	价格	上海	北京	珠海	重庆	武汉
S82073-1mg买3赠1	98.97%	￥230.00 S82073-1mg ￥230.00 现货（买3赠1）	6 4 6	2	2	-	-
S82073-5mg买3赠1	98.97%	￥310.00 S82073-5mg ￥310.00 现货（买3赠1）	4 4	-	-	-	-
S82073-10mg买3赠1	≥98%	￥552.00 S82073-10mg ￥552.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S82073-25mg买3赠1	≥98%	￥1270.00 S82073-25mg ￥1270.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S82073-50mg买3赠1	≥98%	￥2120.00 S82073-50mg ￥2120.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies

靶点：

Potassium Channel;EGFR; PotassiumChannel

体外研究：

E-4031 (0.1-10 μM) significantly depolarises the maximum diastolic potential (MDP) and prolongs the action charge that depolarises MDP from -58.8+0.9 to -24.5±1.8 mV at 1 μM and from -58.2±2.1 to -19.6±1.8 mV at 10 μM in single SAN cells of New Zealand albinc rabbits. E-4031 (0.1-10 μM) can block part of the outward current during the depolarisation step as well as the tail current (ITD) during subsequent repolarization in a dose-dependent manner, and depresses ITD by 88 % at 10 μM in single SAN cells of New Zealand albinc rabbits

体内研究：

E-4031 (i.v., 50 μg/kg) reduces the net outward current of ventricular myocytes, prolongs the QT interval and activation-recovery interval (ARI) in all left ventricular (LV) layers, and increases transmural ARI dispersion in beagles

参考文献：

1. Daisuke Izumi, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33(8):950-9. 2. E E Verheijck, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76(4):607-15.

溶解性：

Soluble in H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.108 ml	10.539 ml	21.077 ml
5 mM	0.422 ml	2.108 ml	4.215 ml
10 mM	0.211 ml	1.054 ml	2.108 ml
50 mM	0.042 ml	0.211 ml	0.422 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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