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E-4031

    
98.97%

E-4031

源叶(MedMol)
S82073 一键复制产品信息
113559-13-0
C21H29Cl2N3O3S
474.4443
PDZ1 Domain inhibitor peptide; E-4031; E 4031 dihydrochloride;
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S82073-1mg买3赠1
98.97%

¥230.00

6 2 2 - -
S82073-5mg买3赠1
98.97%

¥310.00

4 - - - -
S82073-10mg买3赠1
≥98%

¥552.00

货期:2-3天 - - - -
S82073-25mg买3赠1
≥98%

¥1270.00

货期:2-3天 - - - -
S82073-50mg买3赠1
≥98%

¥2120.00

货期:2-3天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies
靶点: Potassium Channel;EGFR; PotassiumChannel
体外研究: E-4031 (0.1-10 μM) significantly depolarises the maximum diastolic potential (MDP) and prolongs the action charge that depolarises MDP from -58.8+0.9 to -24.5±1.8 mV at 1 μM and from -58.2±2.1 to -19.6±1.8 mV at 10 μM in single SAN cells of New Zealand albinc rabbits. E-4031 (0.1-10 μM) can block part of the outward current during the depolarisation step as well as the tail current (ITD) during subsequent repolarization in a dose-dependent manner, and depresses ITD by 88 % at 10 μM in single SAN cells of New Zealand albinc rabbits
体内研究: E-4031 (i.v., 50 μg/kg) reduces the net outward current of ventricular myocytes, prolongs the QT interval and activation-recovery interval (ARI) in all left ventricular (LV) layers, and increases transmural ARI dispersion in beagles
参考文献: 1. Daisuke Izumi, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33(8):950-9. 2. E E Verheijck, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76(4):607-15.
溶解性: Soluble  in  H2O
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.108 ml 10.539 ml 21.077 ml
5 mM 0.422 ml 2.108 ml 4.215 ml
10 mM 0.211 ml 1.054 ml 2.108 ml
50 mM 0.042 ml 0.211 ml 0.422 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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