| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82107-1mg买3赠1 |
99.80% | ￥186.00 |
>10 | - | - | - | - |
|
S82107-5mg买3赠1 |
99.80% | ￥410.00 |
>10 | - | - | - | - |
|
S82107-10mg买3赠1 |
99.80% | ￥520.00 |
>10 | - | - | - | - |
|
S82107-25mg买3赠1 |
99.80% | ￥820.00 |
>10 | - | - | - | - |
|
S82107-50mg买3赠1 |
99.80% | ￥1200.00 |
>10 | - | - | - | - |
|
S82107-100mg买3赠1 |
99.80% | ￥1800.00 |
>10 | - | - | - | - |
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| 产品描述： | J-147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J-147 can readily pass the blood brain barrier (BBB). J-147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. J-147 has potential for the treatment of Alzheimer’s disease (AD) | ||||||||||||||||||||
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| 靶点： | MAO B; Dopamine transporter;EpigeneticReaderDomain; DopamineReceptor; MonoamineOxidase | ||||||||||||||||||||
| 体外研究： | J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06-0.115 μM) | ||||||||||||||||||||
| 体内研究： | J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice. The half life (t1/2) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg). Animal Model: 24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls Dosage: 200 ppm Administration: The diet was prepared by the addition of 200ppm; 6 months Result: While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147. | ||||||||||||||||||||
| 参考文献： | 1. Wang M, et al. The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23(2):524-7. 2. Prior M, et al. The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimers Res Ther. 2013 May 14;5(3):25. 3. Chen Q, et al. A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One. 2011;6(12):e27865. 4. Prior M, et al. Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery. Alzheimers Dement. 2016 Jun;12(6):678-86. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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