品牌：源叶(MedMol)

产品编号：S82157 一键复制产品信息

CAS号：1163-36-6

分子式：C₁₉H₂₁Cl₂N₃

分子量：362.296

别名：1-[(4-氯苯基)甲基]-2-(吡咯烷-1-基甲基)苯并咪唑盐酸盐;盐酸氯咪唑;1-对氯苄基-2-(1-吡咯烷基)甲基苯并咪唑盐酸盐;1-(p-chlorobenzil)-2-pirrolidil-metil-benzimidazolocloridato;1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)-benzimidazolmonohydrochlor

货号	规格	价格	上海	北京	珠海	重庆	武汉
S82157-2mg买3赠1	99.50%	￥60.00 S82157-2mg ￥60.00 现货（买3赠1）	5 5	-	-	-	-
S82157-5mg	99.50%	￥85.00 S82157-5mg ￥85.00 现货	5 5	-	-	-	-
S82157-10mg	99.50%	￥140.00 S82157-10mg ￥140.00 现货	7 7	-	-	-	-
S82157-25mg	99.50%	￥300.00 S82157-25mg ￥300.00 现货	2 2	-	-	-	-
S82157-50mg	≥99%	￥500.00 S82157-50mg ￥500.00 2-3天	0 货期：2-3天	-	-	-	-
S82157-100mg	≥99%	￥900.00 S82157-100mg ￥900.00 2-3天	0 货期：2-3天	-	-	-	-
S82157-200mg	≥99%	￥1700.00 S82157-200mg ￥1700.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole hydrochloride is an inhibitor of TRPC5 channel. The IC50 of Clemizole hydrochloride for RNA binding by NS4B is 24 nM, whereas its EC50 for viral replication is 8 µM

靶点：

IC50: 24 nM (NS4B) H1 histamine receptor;HCVProtease; HistamineReceptor

体内研究：

Clemizole hydrochloride has an unexpectedly short plasma half-life (measured at 0.15 hours); it is very rapidly biotransformed into a glucuronide (M14) and a dealkylated metabolite (M12) and into a variety of lesser metabolites in C57BL/6J mice

参考文献：

1. Einav S, et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27 2. Richter JM, et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21 3. Nishimura T, et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96.

溶解性：

DMSO : 33.33 mg/mL (92.00 mM; Need ultrasonic) H2O : 20 mg/mL (55.20 mM; Need ultrasonic)

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.76 ml	13.801 ml	27.602 ml
5 mM	0.552 ml	2.76 ml	5.52 ml
10 mM	0.276 ml	1.38 ml	2.76 ml
50 mM	0.055 ml	0.276 ml	0.552 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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