货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S82167-5mg	≥98%	￥2190.00 S82167-5mg ￥2190.00 3-5天	0 货期：3-5天	-	-	-	-
S82167-10mg	≥98%	￥3890.00 S82167-10mg ￥3890.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

AZD7687 is a potent, selective, reversible and orally active diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC50 of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research

靶点：

Acyltransferase;Others

体内研究：

Prolonged pharmacological inhibition of DGAT1 with AZD7687 in mice results in the same skin phenotype, including sebaceous gland atrophy and alopecia, as seen in the skin of DGAT1-/- mice. AZD7687-mediated effects on the skin were dose- and time-dependent and reversible

参考文献：

1. Barlind JG, et al. Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem. 2012 Dec 13;55(23):10610-29. 2. Denison H, et al. Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial. Diabetes Obes Metab. 2013 Oct 4. 3. Eike Floettmann, et al. Pharmacological inhibition of DGAT1 induces sebaceous gland atrophy in mouse and dog skin while overt alopecia is restricted to the mouse. Toxicol Pathol. 2015 Apr;43(3):376-83.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.722 ml	13.608 ml	27.215 ml
5 mM	0.544 ml	2.722 ml	5.443 ml
10 mM	0.272 ml	1.361 ml	2.722 ml
50 mM	0.054 ml	0.272 ml	0.544 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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