货号	规格	价格	上海	北京	珠海	重庆	武汉
S82174-5mg	99.30%	￥216.00 S82174-5mg ￥216.00 现货	8 8	-	-	-	-
S82174-25mg	99.30%	￥390.00 S82174-25mg ￥390.00 现货	7 7	-	-	-	-
S82174-50mg	≥97%	￥580.00 S82174-50mg ￥580.00 2-3天	0 货期：2-3天	-	-	-	-
S82174-100mg	≥97%	￥870.00 S82174-100mg ￥870.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

靶点：

Amino Acid Derivatives;Others

体外研究：

The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine and TFA, making it completely compatible with standard protocols in Fmoc solid phase peptide synthesis. The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (Tn +antigen). This precursor is generated in the Golgi apparatus on newly synthesized glycoproteins by a family of polypeptide α- N-acetylgalactosaminyltransferases (ppGalNAcTs) and then extended to the common core 1 O-glycan Galβ1-3GalNAcα1-OSer/Thr (T antigen) by a single enzyme termed the T-synthase (core 1 β3-galactosyltransferase or C1GalT). Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome.

参考文献：

1. Ju T, et al. The Cosmc connection to the Tn antigen in cancer. Cancer Biomark. 2014 Jan 1;14(1):63-81.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.491 ml	7.455 ml	14.911 ml
5 mM	0.298 ml	1.491 ml	2.982 ml
10 mM	0.149 ml	0.746 ml	1.491 ml
50 mM	0.03 ml	0.149 ml	0.298 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH