货号	规格	价格	上海	北京	珠海	重庆	武汉
S82263-5mg促销	≥98%	￥122.00 ￥110.00 S82263-5mg ￥110.00 现货	10 10	-	-	-	-
S82263-25mg促销	≥98%	￥400.00 ￥360.00 S82263-25mg ￥360.00 现货	10 10	-	-	-	-
S82263-100mg促销	≥98%	￥1270.00 ￥1140.00 S82263-100mg ￥1140.00 现货	3 3	-	-	-	-
S82263-250mg促销	≥98%	￥2210.00 ￥1990.00 S82263-250mg ￥1990.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC-54252 attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of ~1 nM. CZC-54252 has a neuroprotective activity

靶点：

IC50: 1.28 nM (Wild-type LRRK2) and 1.85 nM (G2019S LRRK2);LRRK2

体外研究：

CZC-54252 inhibits the activity of recombinant human wild-type LRRK2 with an IC50 ranging from ～1 to ～5 nM. The G2019S mutant is inhibited with an IC50 ranging from ～2 to ～7 nM in a TF-FRET assay. In addition, they are screened against a kinase panel of 185 kinases and exhibited good selectivity. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 with an EC50 of ~1 nM and fully reversed to wild-type levels by CZC-54252 at concentration of 1.6 nM

参考文献：

1. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.98 ml	9.901 ml	19.802 ml
5 mM	0.396 ml	1.98 ml	3.96 ml
10 mM	0.198 ml	0.99 ml	1.98 ml
50 mM	0.04 ml	0.198 ml	0.396 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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