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产品描述： Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects |
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靶点：
Estrogen Receptor/ERR;EstrogenReceptor/ERR; Estrogen/progestogenReceptor |
体外研究：
Endoxifen E-isomer (1-1000 nM; 12 h) inhibits PGR gene expression in E2-induced MCF-7 cells |
参考文献：
1. Elkins P, et, al. Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9. 2. Zheng Y, et, al. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos. 2007 Oct;35(10):1942-8. |
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溶解性：
soluble in DMSO |
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保存条件：
-20℃ |
配置溶液浓度参考：
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1mg |
5mg |
10mg |
| 1 mM |
2.439 ml |
12.197 ml |
24.393 ml |
| 5 mM |
0.488 ml |
2.439 ml |
4.879 ml |
| 10 mM |
0.244 ml |
1.22 ml |
2.439 ml |
| 50 mM |
0.049 ml |
0.244 ml |
0.488 ml |
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| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
北京