货号	规格	价格	上海	北京	珠海	重庆	武汉
S82354-1mg	98.82%	￥590.00 S82354-1mg ￥590.00 现货	9 9	-	-	-	-
S82354-5mg	≥98%	￥1480.00 S82354-5mg ￥1480.00 现货	8 8	-	-	-	-
S82354-25mg促销	≥98%	￥4000.00 ￥3600.00 S82354-25mg ￥3600.00 现货	6 6	-	-	-	-
S82354-100mg促销	98.82%	￥7330.00 ￥6590.00 S82354-100mg ￥6590.00 现货	8 8	-	-	-	-

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产品描述：

Cibinetide (ARA290) 是一种 EPO 衍生物，为特异性的促红细胞生成素/ CD131 受体激动剂 (erythropoietin/CD131 heteroreceptor) 的激动剂。Cibinetide 可用于神经系统疾病研究。

靶点：

Peptides;Others

体外研究：

Cibinetide (ARA290) enhances the proliferation, migration, and resistance to H2O2-induced apoptosis of endothelial colony-forming cells (ECFCs). Cibinetide (ARA290) is an EPO-analog peptide without hematopoietic side-effects but may have neurotrophic and antidepressant effects

体内研究：

After ECFC transplantation to mice with CLI, a single Cibinetide (ARA290) injection enhances the ischemic/non-ischemic ratio of hindlimb blood flow and capillary density after 28 days and the homing of radiolabeled transplanted cells to the ischemic leg 4 h after transplantation. Cibinetide (ARA290; 30 μg/kg, s.c.) prevents progressive worsening of glucose control without affecting body weight of rats. Cibinetide significantly decreases glucose AUCs in IPGTT in GK rats. Low-dosage Cibinetide (35 μg/kg, i.p.) treatment only slightly attenuates the EAE severity in rats. Cibinetide-treating group (70 μg/kg, i.p.) significantly delays the onset, decreases the neurologic severity and shortens the duration of EAE in a dose-dependent way

参考文献：

1. Hache G, et al. ARA290, a Specific Agonist of Erythropoietin/CD131 Heteroreceptor, Improves Circulating Endothelial Progenitors' Angiogenic Potential and Homing Ability. Shock. 2016 Oct;46(4):390-7
2. Carole Muller, et al. ARA290 Improves Insulin Release and Glucose Tolerance in Type 2 Diabetic Goto-Kakizaki Rats. Mol Med. 2015; 21(1): 969–978
3. Chen H, et al. Therapeutic effects of nonerythropoietic erythropoietin analog ARA290 in experimental autoimmune encephalomyelitis rat. J Neuroimmunol. 2014 Mar 15;268(1-2):64-70

溶解性：

soluble in DMSO

保存条件：

-20℃，氮气保存

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.795 ml	3.977 ml	7.954 ml
5 mM	0.159 ml	0.795 ml	1.591 ml
10 mM	0.08 ml	0.398 ml	0.795 ml
50 mM	0.016 ml	0.08 ml	0.159 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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