| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82362-5mg买3赠1 |
99.70% | ￥350.00 |
6 | - | - | - | - |
|
S82362-10mg买3赠1 |
99.70% | ￥540.00 |
7 | - | - | - | - |
|
S82362-25mg促销 |
99.70% | ￥1270.00 ￥1010.00 |
5 | - | - | - | - |
|
S82362-100mg促销 |
≥99% | ￥3360.00 ￥2680.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively | ||||||||||||||||||||
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| 靶点： | IC50: 2 nM (FAAH), 4 nM (MAGL);FAAH; Lipase; Autophagy | ||||||||||||||||||||
| 体外研究： | JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively). JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays | ||||||||||||||||||||
| 体内研究： | JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay. Animal Model: Male C57BL/6J mice Dosage: 20 mg/kg Administration: Intraperitoneal injection Result: Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone. | ||||||||||||||||||||
| 参考文献： | 1. Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5. 2. Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology. 2014 Jun;81:224-30. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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