货号	规格	价格	上海	北京	珠海	重庆	武汉
S82380-1mg	≥98%	￥1110.00 S82380-1mg ￥1110.00 3-5天	0 货期：3-5天	-	-	-	-
S82380-5mg	≥98%	￥2790.00 S82380-5mg ￥2790.00 3-5天	0 货期：3-5天	-	-	-	-
S82380-10mg	≥98%	￥4390.00 S82380-10mg ￥4390.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC50 values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock

靶点：

Platelet-activating Factor Receptor (PAFR);Others

体内研究：

In rats, TCV-309 selectively inhibits the PAF-induced hypotension, hemoconcentration and death with ED50 values of 2.7, 6.4 and 1.7 micrograms/kg (i.v.), respectively. TCV-309 most potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 values of 2.1 and 2.6 micrograms/kg (i.v.), respectively. TCV-309 chloride also reversed PAF-induced hypotension and endotoxin-induced hypotension in rats with ED50 values of 3.3 and 1.2 micrograms/kg (i.v.), respectively

参考文献：

1. Terashita Z et al. Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55. 2. M Poeze, et al. Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II trial. TCV-309 Septic Shock Study Group. Shock. 2000 Oct;14(4):421-8.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.587 ml	7.937 ml	15.874 ml
5 mM	0.317 ml	1.587 ml	3.175 ml
10 mM	0.159 ml	0.794 ml	1.587 ml
50 mM	0.032 ml	0.159 ml	0.317 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

计算重置

TCV-309 (chloride)