| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82384-5mg促销 |
≥98% | ￥230.00 ￥206.00 |
10 | - | - | - | - |
|
S82384-10mg促销 |
≥98% | ￥342.00 ￥306.00 |
10 | - | - | - | - |
|
S82384-25mg促销 |
≥98% | ￥460.00 ￥414.00 |
7 | - | - | - | - |
|
S82384-50mg促销 |
≥98% | ￥688.00 ￥619.00 |
2 | - | - | - | - |
|
S82384-100mg促销 |
≥98% | ￥1200.00 ￥1080.00 |
2 | - | - | - | - |
|
| 产品描述： | CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). | ||||||||||||||||||||
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| 靶点： | 5-HT Receptor;5-HTReceptor | ||||||||||||||||||||
| 体外研究： | CP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro | ||||||||||||||||||||
| 体内研究： | Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively, and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test, and learned helplessness | ||||||||||||||||||||
| 参考文献： | 1. Siuciak JA, Chapin DS, McCarthy SA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52(2):279-90. 2. Higgins GA, Silenieks LB, Lau W, et al. Evaluation of chemically diverse 5-HT2C receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. 3. Strong PV, Christianson JP, Loughridge AB, et al. 5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior. Neuroscience. 2011 Dec 1;197:132-44. doi: 10.1016/j.neuroscience.2011.09.041. Epub 2011 Sep 24. 4. Fletcher PJ, Tampakeras M, Sinyard J et al. Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. Neuropharmacology. 2009 Sep;57(3):259-67. doi: 10.1016/j.neuropharm.2009.05.011. | ||||||||||||||||||||
| 溶解性： | Soluble in H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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