| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S82480-2mg |
99.8% | ￥150.00 | 5 | - | - | - |
|
S82480-5mg |
99.8% | ￥220.00 | 6 | - | - | - |
|
S82480-10mg |
99.8% | ￥380.00 | 5 | - | - | - |
|
S82480-25mg |
99.8% | ￥770.00 | 6 | - | - | - |
|
S82480-50mg |
99.8% | ￥1300.00 | 5 | - | - | - |
|
S82480-100mg |
≥98% | ￥2220.00 | 货期：2-3天 | - | - | - |
|
HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.
| 产品描述： | HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Autotaxin:28 nM (IC50);PDE | ||||||||||||||||||||
| 体内研究： | HA130 slows T cell migration across lymph node HEVs. HA130 decreases the outside HEVs/inside HEVs ratio by 3-4-fold compared to vehicle-treated animals vehicle. The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs) | ||||||||||||||||||||
| 参考文献： | 1. Zhang Y, et al. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15;189(8):3914-3924. 2. Bai Z, et al. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by theautotaxin/lysophosphatidic acid axis. J Immunol. 2013 Mar 1;190(5):2036-2048. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 39 mg/mL (84.18 mM) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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