| 产品描述： | HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM. |
| 靶点： |
Autotaxin:28 nM (IC50);PDE |
| 体内研究： |
HA130 slows T cell migration across lymph node HEVs. HA130 decreases the outside HEVs/inside HEVs ratio by 3-4-fold compared to vehicle-treated animals vehicle. The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs) |
| 参考文献： |
1. Zhang Y, et al. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15;189(8):3914-3924. 2. Bai Z, et al. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by theautotaxin/lysophosphatidic acid axis. J Immunol. 2013 Mar 1;190(5):2036-2048. |
| 溶解性： |
DMSO : ≥ 39 mg/mL (84.18 mM) |
| 保存条件： |
2-8℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.158 ml |
10.792 ml |
21.585 ml |
| 5 mM |
0.432 ml |
2.158 ml |
4.317 ml |
| 10 mM |
0.216 ml |
1.079 ml |
2.158 ml |
| 50 mM |
0.043 ml |
0.216 ml |
0.432 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京