| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82495-1mg |
≥98% | ￥280.00 |
货期：3-5天 | - | - | - | - |
|
S82495-2mg |
≥98% | ￥440.00 |
货期：3-5天 | - | - | - | - |
|
S82495-5mg |
≥98% | ￥690.00 |
货期：3-5天 | - | - | - | - |
|
S82495-10mg |
≥98% | ￥1190.00 |
货期：3-5天 | - | - | - | - |
|
S82495-25mg |
≥98% | ￥2470.00 |
货期：3-5天 | - | - | - | - |
|
S82495-50mg |
≥98% | ￥3710.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also has antitumor activity. | ||||||||||||||||||||
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| 靶点： | PKD1:28.3 nM (IC50);PKD3:53.2 nM (IC50);PKD2:58.7 nM (IC50);Serine/threoninkinase | ||||||||||||||||||||
| 体外研究： | kb NB 142-70 is a potent PKD inhibitor, with IC50s of 28.3, 58.7 and 53.2 nM for PKD1, PKD2, and PKD3, respectively. kb NB 142-70 also inhibits Ser916 phosphorylation of PKD1 (IC50, 2.2 ± 0.6 μM) in LNCaP cells. Moreover, kb NB 142-70 is cytotoxic against PC3 cells with an EC50 of 8.025 μM. kb NB 142-70 (0-5 μM) concentration-dependently prevents ANG II-induced phosphorylation of HDAC4 at Ser246 and Ser632, HDAC5 at Ser259 and Ser498, and HDAC7 at Ser155 in IEC-18 cells. In addition, kb NB 142-70 (3.5 μM) also suppresses HDAC4, HDAC5, and HDAC7 phosphorylation in IEC-18 cells stimulated with ANG II for 0-240 min or with vasopressin, lysophosphatidic acid (LPA), or phorbol 12,13-dibutyrate (PDBu). | ||||||||||||||||||||
| 参考文献： | 1. Lavalle CR, et al. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. BMC Chem Biol. 2010 May 5;10:5. 2. James Sinnett-Smith, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15; 306(10): C961-C971. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京