| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82514-1mg |
≥99% | ￥580.00 |
5 | - | - | - | - |
|
S82514-5mg |
≥99% | ￥1250.00 |
5 | - | - | - | - |
|
S82514-10mg |
≥99% | ￥2000.00 |
2 | - | - | - | - |
|
S82514-25mg |
≥99% | ￥3600.00 |
3 | - | - | - | - |
|
S82514-50mg |
≥99% | ￥5400.00 |
2 | - | - | - | - |
|
| 产品描述： | Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research | ||||||||||||||||||||
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| 靶点： | IC50: 0.31 μM (LeuRS);Antibacterial | ||||||||||||||||||||
| 体外研究： | Epetraborole (0-32 μg/mL) shows anti-bacterial activity against key gram-negative aerobic and anaerobic pathogens and gram-positive anaerobes. Cell Viability Assay Cell Line: Anaerobes isolates Concentration: 0-32 μg/mL Incubation Time: Result: Showed MIC50/MIC90 for all anaerobes isolates tested of 2 and 4 μg/mL, respectively. | ||||||||||||||||||||
| 参考文献： | 1. Goldstein EJ, et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms. Antimicrob Agents Chemother. 2013 May;57(5):2401-4. 2. O'Dwyer K, et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. 3. Sutcliffe JA. Antibiotics in development targeting protein synthesis. Ann N Y Acad Sci. 2011 Dec;1241:122-52. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、H2O | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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