货号	规格	价格	上海	北京	珠海	重庆	武汉
S82524-5mg买3赠1	99.90%	￥400.00 S82524-5mg ￥400.00 现货（买3赠1）	6 6	-	-	-	-
S82524-10mg买3赠1	99.90%	￥690.00 S82524-10mg ￥690.00 现货（买3赠1）	8 8	-	-	-	-
S82524-25mg买3赠1	99.90%	￥1400.00 S82524-25mg ￥1400.00 现货（买3赠1）	3 3	-	-	-	-
S82524-100mg买3赠1	99.90%	￥2900.00 S82524-100mg ￥2900.00 现货（买3赠1）	4 4	-	-	-	-

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产品描述：

P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury treatment

体内研究：

P7C3-A20 (5-10 mg/kg; intraperitoneal injection; daily; for 7 days; Sprague-Dawley rats) treatment reduces infarct volume; reverses cell loss in the cortex and hippocampus and improves motor function without causing neurotoxicity in HI model rats. P7C3-A20 prevents HI-induced neuronal injury via activation of the PI3K/AKT/GSK3β signaling pathway. Animal Model: Sprague-Dawley rats (200-250 g) induced hypoxic-ischemic (HI) injury Dosage: 5 mg/kg, 10 mg/kg Administration: Intraperitoneal injection; daily; for 7 days Result: Reduced infarct volume; reversed cell loss in the cortex and hippocampus and improved motor function without causing neurotoxicity.

参考文献：

1. Junjie Bai, et al. The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-Ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3β Signaling. Neuroscience. 2020 Jun 3;S0306-4522(20)30353-5. 2. Blaya MO et al. Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury. J Neurotrauma. 2014 Mar 1;31(5):476-86. 3. Walker AK et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasinghippocampal neurogenesis. Mol Psychiatry. 2015 Apr;20(4):500-8.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.975 ml	9.877 ml	19.755 ml
5 mM	0.395 ml	1.975 ml	3.951 ml
10 mM	0.198 ml	0.988 ml	1.975 ml
50 mM	0.04 ml	0.198 ml	0.395 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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