货号	规格	价格	上海	北京	珠海	重庆	武汉
S82609-5mg	≥99%	￥330.00 S82609-5mg ￥330.00 现货	10 10	-	-	-	-
S82609-10mg	≥99%	￥594.00 S82609-10mg ￥594.00 现货	9 0 9	-	-	-	-
S82609-25mg	≥99%	￥1260.00 S82609-25mg ￥1260.00 现货	5 0 5	-	-	-	-
S82609-50mg	≥99%	￥2140.00 S82609-50mg ￥2140.00 现货	5 5	-	-	-	-
S82609-100mg	≥99%	￥3640.00 S82609-100mg ￥3640.00 现货	3 3	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

BMS-986020 (AM152, AP-3152 free acid) 是一种有效的 lysophosphatidic acid receptor 1 (LPA1) 的选择性拮抗剂。BMS-986020 可抑制胆汁酸和磷脂转运蛋白，对于BSEP、MRP4和MDR3的IC50值分别为4.8 μM、6.2 μM和7.5 μM。BMS-986020 具有治疗特发性肺纤维化 idiopathic pulmonary fibrosis (IPF) 的潜力

靶点：

LPA1; BSEP(Cell-free assay): 4.8 μM; MRP4(Cell-free assay):6.2 μM; MDR3(Cell-free assay):7.5 μM;LPAReceptor; LPLReceptor

体外研究：

BMS-986020, a selective and potent lysophosphatidic acid receptor 1 (LPA1) inhibitor, inhibits LPA1-induced fibrogenesis in the Scar-in-a-Jar in vitro model

细胞实验：

Cell lines: Human lung fibroblasts Concentrations: 12 days Incubation Time: 0.01, 0.05, 0.1, 0.5, 1, or 5 µM Method: Human lung fibroblasts were cultured in 48-well plates in Dulbecco’s Modified Eagle Medium (DMEM) + GlutaMax with 0.4% fetal bovine serum, 37.5 mg/mL Ficoll 70, 25 mg/mL Ficoll 400, and 1% ascorbic acid. Cells were stimulated with 1 ng/mL transforming growth factor beta 1 (TGF-β1) or 20 µM LPA with or without BMS-986020 (0.01, 0.05, 0.1, 0.5, 1, or 5 µM) diluted in dimethyl sulfoxide (DMSO), or vehicle (0.05% DMSO) in four replicates. Cells were cultured at 37 °C with 95% O2 and 5% CO2 for 12 days, and medium was changed at Day 4 and 8. Supernatants were stored at − 20 °C until biomarker measurements. alamarBlue was used to quantify cellular metabolism at Day 0 (prior to drug treatment) and Day 12. Release of lactate dehydrogenase (LDH) was quantified at Day 4, 8, and 12.

参考文献：

1. Glenn Rosen, et al. LPA1 antagonists BMS-986020 and BMS-986234 for idiopathic pulmonary fibrosis: Preclinical evaluation of hepatobiliary homeostasis. European Respiratory Journal 2017 50: PA1038; vol. 50 no. suppl 61. 2. Decato BE, et al. LPA1 antagonist BMS-986020 changes collagen dynamics and exerts antifibrotic effects in vitro and in patients with idiopathic pulmonary fibrosis. Respir Res. 2022 Mar 18;23(1):61.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.072 ml	10.362 ml	20.724 ml
5 mM	0.414 ml	2.072 ml	4.145 ml
10 mM	0.207 ml	1.036 ml	2.072 ml
50 mM	0.041 ml	0.207 ml	0.414 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置