货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S82626-5mg	≥99%	￥2600.00 S82626-5mg ￥2600.00 3-5天	0 货期：3-5天	-	-	-	-
S82626-10mg	≥99%	￥4330.00 S82626-10mg ￥4330.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

GSK 525768A is the inactive enantiomer of GSK525762A. GSK 525768A has no activity towards BET.

靶点：

Others

体外研究：

GSK 525768A has no activity towards BET. GSK 525768A (GSK525768A) is the (R)-enantiomer of GSK525762A. GSK525762A is shown to regulate levels of the high-density lipid protein apolipoprotein A1 (APOA1) in assays monitoring APOA1 release in liver cells, whereas the (R)-enantiomer (GSK 525768A) has no effect. GSK 525768A directly engages the protein module by forming hydrogen bonds with the conserved asparagine residue in a way that mimics the binding mode of acetylated lysine; this usually results in the binding of the inhibitor deeper within the acetylated lysine binding site but without displacing the conserved water molecules that are present at the bottom of the acetyl-lysine binding cavity

参考文献：

1. Nicodeme E, et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468(7327):1119-23. 2. Filippakopoulos P, et al. Targeting bromodomains: epigenetic readers of lysine acetylation. Nat Rev Drug Discov. 2014 May;13(5):337-56.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.359 ml	11.795 ml	23.591 ml
5 mM	0.472 ml	2.359 ml	4.718 ml
10 mM	0.236 ml	1.18 ml	2.359 ml
50 mM	0.047 ml	0.236 ml	0.472 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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