货号	规格	价格	上海	北京	珠海	重庆	武汉
S82637-1mg	≥99%	￥200.00 S82637-1mg ￥200.00 现货	10 10	-	-	-	-
S82637-5mg	≥99%	￥300.00 S82637-5mg ￥300.00 现货	7 7	-	-	-	-
S82637-10mg	≥99%	￥510.00 S82637-10mg ￥510.00 现货	10 10	-	-	-	-
S82637-50mg	≥99%	￥1300.00 S82637-50mg ￥1300.00 现货	7 7	-	-	-	-
S82637-100mg	≥99%	￥2300.00 S82637-100mg ￥2300.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

GS-444217 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM

靶点：

ASK1:2.87 nM (IC50);Apoptosis; ASK; MAPK

体外研究：

Treatment with GS-444217 reduces ASK1 phosphorylation and prevents the phosphorylation of MKK3/6, MKK4, p38, and JNK at concentrations of 0.3 μM and above with full suppression of ASK1 activity at 1 μM. GS-444217 (1 μM) reduces ASK1 activity within 5 minutes of addition to the cultures, reaching a maximum level of inhibition by 30 minutes. Removal of GS-444217 from the cultures results in reactivation of ASK1 autophosphorylation within 10 minutes and near-complete recovery 2 hours after drug washout

体内研究：

GS-444217 reduces oxidative stress (OS)-induced ASK1 signaling in kidney and inhibits acute renal tubular injury in rats. GS-444217 (30 mg/kg) inhibits activation of ASK1, p38, and JNK in rat kidney. GS-444217 has an in vivo EC50 of approximately 1.6 μM for inhibiting the ASK1 pathway in rodent kidney[1]

参考文献：

1. Liles JT, et al. ASK1 contributes to fibrosis and dysfunction in models of kidney disease. J Clin Invest. 2018 Oct 1;128(10):4485-4500. 2. Budas GR, et al. ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2018 Feb 1;197(3):373-385.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.43 ml	12.152 ml	24.304 ml
5 mM	0.486 ml	2.43 ml	4.861 ml
10 mM	0.243 ml	1.215 ml	2.43 ml
50 mM	0.049 ml	0.243 ml	0.486 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

ASK1-IN-1