品牌：源叶(MedMol)

产品编号：S82687 一键复制产品信息

CAS号：1273323-67-3

分子式：C₂₉H₂₀ClNO₃

分子量：465.927

别名：(E)-3-((3-((4-chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid; 3-{3-[1-(4-chloro-phenyl)-1-phenyl-meth-(E)-ylidene]-2-oxo-2,3-dihydro-indol-1-ylmethyl}-benzoic acid; 3-{3-[1-(4-c

货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S82687-5mg	≥99%	￥1010.00 S82687-5mg ￥1010.00 3-5天	0 货期：3-5天	-	-	-	-
S82687-10mg	≥99%	￥1700.00 S82687-10mg ￥1700.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.

靶点：

AMPK

体外研究：

The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively

参考文献：

1. Liu Y, et al. Antiplatelet effect of a newly developed AMP-activated protein kinase activator YLF-466D. Eur J Pharmacol. 2015 Aug 5;760:81-7.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.146 ml	10.731 ml	21.463 ml
5 mM	0.429 ml	2.146 ml	4.293 ml
10 mM	0.215 ml	1.073 ml	2.146 ml
50 mM	0.043 ml	0.215 ml	0.429 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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