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chroman 1

    
≥98%

chroman 1

源叶(MedMol)
S82688 一键复制产品信息
1273579-40-0
C24H28N4O4
436.5035
CS-0775; ROCK-II inhibitor;
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S82688-1mg促销
≥98%

¥490.00 ¥440.00

4 - - - -
S82688-5mg促销
≥98%

¥2100.00 ¥1890.00

5 - - - -
S82688-10mg促销
≥98%

¥3400.00 ¥3060.00

2 - - - -
S82688-25mg促销
≥98%

¥4130.00 ¥3710.00

1 - - - -
S82688-50mg促销
≥98%

¥7840.00 ¥7060.00

1 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM
靶点: ROCK2:1 pM (IC50);ROCK1:52 pM (IC50);MRCK:150 nM (IC50);ROCK
体外研究: Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells. Apoptosis Analysis Cell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 0-12 h or 24 h Result: Reduced the number of apoptotic cells, reduced caspase-3/7 activation. Western Blot Analysis Cell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 24 h Result: Partially inhibited caspase-3 activation.
参考文献: 1. Yu Chen, et al. A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells. bioRxiv 815761. 2. Yen Ting Chen, et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun., 2011, 2, 73-75.
溶解性: soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.291 ml 11.455 ml 22.909 ml
5 mM 0.458 ml 2.291 ml 4.582 ml
10 mM 0.229 ml 1.145 ml 2.291 ml
50 mM 0.046 ml 0.229 ml 0.458 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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