| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82688-1mg促销 |
≥98% | ￥490.00 ￥440.00 |
4 | - | - | - | - |
|
S82688-5mg促销 |
≥98% | ￥2100.00 ￥1890.00 |
5 | - | - | - | - |
|
S82688-10mg促销 |
≥98% | ￥3400.00 ￥3060.00 |
2 | - | - | - | - |
|
S82688-25mg促销 |
≥98% | ￥4130.00 ￥3710.00 |
1 | - | - | - | - |
|
S82688-50mg促销 |
≥98% | ￥7840.00 ￥7060.00 |
1 | - | - | - | - |
|
| 产品描述： | Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM | ||||||||||||||||||||
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| 靶点： | ROCK2:1 pM (IC50);ROCK1:52 pM (IC50);MRCK:150 nM (IC50);ROCK | ||||||||||||||||||||
| 体外研究： | Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells. Apoptosis Analysis Cell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 0-12 h or 24 h Result: Reduced the number of apoptotic cells, reduced caspase-3/7 activation. Western Blot Analysis Cell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 24 h Result: Partially inhibited caspase-3 activation. | ||||||||||||||||||||
| 参考文献： | 1. Yu Chen, et al. A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells. bioRxiv 815761. 2. Yen Ting Chen, et al. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. Med.Chem.Commun., 2011, 2, 73-75. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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