HOE 140

99.70%

HOE 140

质检下载产品说明书产品使用指南

品牌：源叶(MedMol)

产品编号：S82767 一键复制产品信息

CAS号：130308-48-4

分子式：C₅₉H₈₉N₁₉O₁₃S

分子量：1304.52

别名：艾替班特;RRP-(HYP)-G-(THI)-S-(D-TIC)-(OIC)-R;H-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH;H2N-D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-TIC-OIC-ARG-OH;HOE 140;HOE 140 2ACOH 4H2O;D-ARG-ARG-PRO-HYP-GLY-THI-SER-D-

货号	规格	价格	上海	北京	珠海	重庆	武汉
S82767-1mg	99.70%	￥460.00 S82767-1mg ￥460.00 现货	5 5	-	-	-	-
S82767-5mg	99.70%	￥1690.00 S82767-5mg ￥1690.00 现货	6 6	-	-	-	-
S82767-10mg	99.70%	￥2130.00 S82767-10mg ￥2130.00 现货	6 6	-	-	-	-

大包装询价收藏产品

加入购物车

产品介绍参考文献(1篇) 质检证书(COA) 摩尔浓度计算器相关产品

产品描述：

Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively

靶点：

Bradykinin B2 Receptor (B2R);Others

体内研究：

Icatibant (0.3, or 1.5 mg/kg, subcutaneous administration twice daily in mice) shows a significant preventive effect on ulcerative Colitis

参考文献：

1. Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73. 2. Y Arai, et al. Effect of Icatibant, a Bradykinin B2 Receptor Antagonist, on the Development of Experimental Ulcerative Colitis in Mice. Dig Dis Sci. 1999 Apr;44(4):845-51. 3. Marie-Thérèse Bawolak, et al The Bradykinin B2 Receptor Antagonist Icatibant (Hoe 140) Blocks Aminopeptidase N at Micromolar Concentrations: Off-Target Alterations of Signaling Mediated by the Bradykinin B1 and Angiotensin Receptors. Eur J Pharmacol. 2006 Dec 3;551(1-3):108-11.

溶解性：

Soluble in H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	0.767 ml	3.833 ml	7.666 ml
5 mM	0.153 ml	0.767 ml	1.533 ml
10 mM	0.077 ml	0.383 ml	0.767 ml
50 mM	0.015 ml	0.077 ml	0.153 ml