| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
| S82780-5mg | 99% | ￥208.00 | 1 | - | - | - |
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| S82780-10mg | 99% | ￥360.00 | 6 | - | - | - |
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| S82780-25mg | 99% | ￥680.00 | 1 | - | - | - |
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| S82780-50mg | 99% | ￥1120.00 | 7 | - | - | - |
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| S82780-100mg | 99% | ￥1680.00 | 3 | - | - | - |
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Entacapone (OR-611) 抑制儿茶酚-O-甲基转移酶(COMT)活性，IC50为151 nM。Entacapone 是一种 FTO demethylation 的抑制剂，IC50为3.5 μM，可用于代谢紊乱的研究
| 产品描述： | Entacapone (OR-611) 抑制儿茶酚-O-甲基转移酶(COMT)活性，IC50为151 nM。Entacapone 是一种 FTO demethylation 的抑制剂，IC50为3.5 μM，可用于代谢紊乱的研究 | ||||||||||||||||||||
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| 靶点： | COMT:151 nM;Transferase | ||||||||||||||||||||
| 体外研究： | Entacapone在不同组织中抑制catechol-O-methyltransferase(COMT)的IC50值大体相似，包括肝脏，十二指肠, 肾脏和肺, 但是entacapone在这些组织中抑制效果比tolcapone更好。 Entacapone (< 100 μM)可以有效抑制α-syn和β-amyloid (Aβ) 齐聚反应和原纤维生成同时可以保护PC12细胞免受这两种蛋白聚集诱导的细胞外毒性 | ||||||||||||||||||||
| 体内研究： | Entacapone administration reduced body weight and lowered fasting blood glucose concentrations in diet-induced obese mice. | ||||||||||||||||||||
| 细胞实验： | Cell lines: PC12 cells Concentrations: 5 μM Incubation Time: 72 h Method: Cells were treated with various concentrations of drug for 72 h. | ||||||||||||||||||||
| 动物实验： | Animal Models: Male C57BL/6 mice Dosages: 600 mg/kg Administration: p.o. | ||||||||||||||||||||
| 参考文献： | 1. De Santi C, et al. Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone. Eur J Clin Pharmacol, 1998, 54(3), 215-219. 2. Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem, 2010, 285(20), 14941-14954. 3. Jenner P, et al. Avoidance of dyskinesia: preclinical evidence for continuous dopaminergic stimulation. Neurology, 2004, 62(1 Suppl 1), S47-55. 4. Hamaue N, et al. Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus. Brain Res, 2010, 1309, 110-115. 5. Peng S, et al. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med. 2019 Apr 17;11(488):eaa | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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