| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82785-1mg买3赠1 |
99.06% | ￥315.00 |
9 | - | - | - | - |
|
S82785-5mg买3赠1 |
99.06% | ￥660.00 |
9 | - | - | - | - |
|
S82785-10mg促销 |
99.06% | ￥1000.00 ￥800.00 |
7 | - | - | - | - |
|
S82785-25mg促销 |
99.06% | ￥1760.00 ￥1400.00 |
6 | - | - | - | - |
|
S82785-50mg促销 |
99.06% | ￥2870.00 ￥2290.00 |
4 | - | - | - | - |
|
S82785-100mg促销 |
≥99% | ￥4630.00 ￥3700.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). IC50 value: 5 nM (in HTRF binding assays), 20 nM (in MTT proliferation assays) Target: MDM2 in vitro: RO8994 represents a new generation of p53-MDM2 antagonists with marked improvement in pharmacological properties for potential clinical development. RO8994 induces dose-dependent up-regulation of p53 target genes and apoptosis in wild-type p53 cancer cells, consistent with its non-genotoxic mechanism of p53 activation. in vivo: RO8994 displays remarkable tumor growth inhibition in the wild-type p53, MDM2-amplified SJSA-1 osteosarcoma tumor xenograft model - exhibiting significant (>60%) tumor growth inhibition at the low dose of 1.56 mg/kg, tumor stasis at 3.125 mg/kg and regression at 6.25 mg/kg. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | MDM-2/p53;E1/E2/E3 Enzyme;Apoptosis;Mdm2; E1/E2/E3Enzyme; p53 | ||||||||||||||||||||
| 体内研究： | RO8994 抑制人 SJSA1 肿瘤异种移植物模型中的肿瘤生长。 | ||||||||||||||||||||
| 参考文献： | 1. Zhang Z, et al. Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg Med Chem. 2014 Aug 1;22(15):4001-4009. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京