货号	规格	价格	上海	北京	珠海	重庆	武汉
S82854-2mg买3赠1	99.40%	￥312.00 S82854-2mg ￥312.00 现货（买3赠1）	3 3	-	-	-	-
S82854-10mg买3赠1	99.40%	￥960.00 S82854-10mg ￥960.00 现货（买3赠1）	1 1	-	-	-	-
S82854-50mg	99.40%	￥2730.00 S82854-50mg ￥2730.00 现货	2 2	-	-	-	-
S82854-100mg	≥97%	￥4080.00 S82854-100mg ￥4080.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

靶点：

PKCγ:6 nM (IC50);PKCα:7 nM (IC50);PKCβ:7 nM (IC50);PKCδ:10 nM (IC50);PKCζ:60 nM (IC50);PKCμ:20000 nM (IC50);PKC

体外研究：

Go 6983 inhibits PKCμ with IC50 of 20 μM, and the pther PKC isoenzymes can be suppressed by Go 6983 with IC50 values from 7 to 60 nM. Go 6983 (100 nM) significantly reduces PMN adherence to the endothelium and infiltration into the myocardium compared with I/R + PMN hearts, and significantly inhibits superoxide release from PMNs by 90 +/- 2% in rat hearts. Go 6983 (200 nM) has a reduced cardioprotective effect compared with the cardioprotective Go 6983 concentrations (50 and 100 nM) despite inhibiting PMN superoxide release by 99%

参考文献：

1. Gschwendt M, et al. Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett, 1996, 392(2), 77-80. 2. Peterman EE, et al. G0 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol, 2004, 43(5), 645-656. 3. Young LH, et al. G0 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev, 2005, 23(3), 255-272.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.26 ml	11.299 ml	22.598 ml
5 mM	0.452 ml	2.26 ml	4.52 ml
10 mM	0.226 ml	1.13 ml	2.26 ml
50 mM	0.045 ml	0.226 ml	0.452 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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