货号	规格	价格	上海	北京	珠海	重庆	武汉
S82876-5mg买3赠1	99.60%	￥352.00 S82876-5mg ￥352.00 现货（买3赠1）	5 5	-	-	-	-
S82876-10mg买3赠1	99.60%	￥664.00 S82876-10mg ￥664.00 现货（买3赠1）	6 6	-	-	-	-
S82876-50mg买3赠1	99.60%	￥2310.00 S82876-50mg ￥2310.00 现货（买3赠1）	2 2	-	-	-	-
S82876-100mg	≥98%	￥3420.00 S82876-100mg ￥3420.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

CHR-6494 is a potent inhibitor of haspin, with an IC50 of 2 nM. CHR-6494 inhibits histone H3T3 phosphorylation. CHR-6494 can be used in the research of cancer

靶点：

haspin:2 nM (IC50);Others

体内研究：

CHR-6494 (50 mg/kg; i.p. in two cycles of five consecutive days for 15 days) inhibits the growth of tumor and cuases no obvious body weight change in nude mice bearing HCT-116 human colorectal cancer cells. CHR-6494 (20 mg/kg; intraperitoneal injection for 15 consecutive days) inhibits the tumor volume and weight compared with the control group in nude mice bearing MDA-MB-231 xenograft tumors. CHR-6494 (20 mg/kg; intraperitoneal injection for 15 consecutive days) enhances the tumor volume and weight inhibition of MLN8237 (20 mg/kg; p.o.) in vivo

参考文献：

1. Huertas D, et al. Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene. 2012 Mar 15;31(11):1408-18. 2. Han L, et al. Anti-Melanoma Activities of Haspin Inhibitor CHR-6494 Deployed as a Single Agent or in a Synergistic Combination with MEK Inhibitor. J Cancer. 2017 Aug 25;8(15):2933-2943. 3. Chen A, et al. CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer. Cancer Commun (Lond). 2021 Feb;41(2):121-139.

溶解性：

DMSO : 50 mg/mL (171.03 mM; Need ultrasonic)

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.421 ml	17.103 ml	34.207 ml
5 mM	0.684 ml	3.421 ml	6.841 ml
10 mM	0.342 ml	1.71 ml	3.421 ml
50 mM	0.068 ml	0.342 ml	0.684 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置