| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82878-1mg买3赠1 |
97.20% | ￥450.00 |
9 | - | - | - | - |
|
S82878-5mg买3赠1 |
97.20% | ￥750.00 |
9 | - | - | - | - |
|
S82878-10mg买3赠1 |
97.20% | ￥1200.00 |
3 | - | - | - | - |
|
S82878-25mg买3赠1 |
≥97% | ￥2400.00 |
货期：2-3天 | - | - | - | - |
|
S82878-50mg |
≥97% | ￥4200.00 |
货期：2-3天 | - | - | - | - |
|
S82878-100mg |
≥97% | ￥6800.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | PF 1022A is a cyclooctadepsipeptide with broadspectrum anthelmintic properties produced by fermentation of the fungus Mycelia sterilia. PF 1022A is a channel-forming ionophore. PF 1022A showes strong anthelmintic activities against Ascaridia galli in chickens. PF 1022A also can be used for angiostrongyliasis research | ||||||||||||||||||||
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| 靶点： | Parasite;Others | ||||||||||||||||||||
| 体外研究： | PF 1022A binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. Furthermore, PF 1022A binds to GABA receptors, which might contribute to the anthelmintic effect. In vitro, PF 1022A shows low activity on embryonation but significantly inhibits egg hatch (10 and 100 μg/mL), whereas albendazole (10 and 100 μg/mL) reveales statistically significant inhibitions of both embryonation and egg hatch. PF 1022A (1-100 μg/mL) completely inhibits larval movement at most examination points | ||||||||||||||||||||
| 参考文献： | 1. Dornetshuber R, et al. Effects of the anthelmintic drug PF1022A on mammalian tissue and cells. Biochem Pharmacol. 2009 Apr 15;77(8):1437-44. 2. Sasaki T, et al. A new anthelmintic cyclodepsipeptide, PF1022A. J Antibiot (Tokyo). 1992 May;45(5):692-7. 3. Nwosu U, et al. Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo. Parasitology. 2011 Aug;138(9):1193-201. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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