货号	规格	价格	上海	北京	珠海	重庆	武汉
S82900-5mg促销	≥98%	￥1550.00 ￥1240.00 S82900-5mg ￥1240.00 现货	10 10	-	-	-	-
S82900-10mg促销	≥98%	￥2590.00 ￥2070.00 S82900-10mg ￥2070.00 现货	10 10	-	-	-	-
S82900-25mg促销	≥98%	￥6180.00 ￥4940.00 S82900-25mg ￥4940.00 现货	8 8	-	-	-	-
S82900-50mg促销	≥98%	￥9990.00 ￥7990.00 S82900-50mg ￥7990.00 现货	4 4	-	-	-	-

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产品描述：

AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane

靶点：

Bacterial;Antibacterial

体外研究：

AU1235 is similarly active against MDR isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum although the MICs (3.2 to 6.4 μg/ml) are significantly higher than against M. tb and M. bovis BCG

参考文献：

1. McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5(5):e00985-20. Published 2020 Oct 14. 2. Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8(4):334-341. Published 2012 Feb 19.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.083 ml	15.416 ml	30.832 ml
5 mM	0.617 ml	3.083 ml	6.166 ml
10 mM	0.308 ml	1.542 ml	3.083 ml
50 mM	0.062 ml	0.308 ml	0.617 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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