| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82906-1mg买3赠1 |
99.00% | ￥158.00 |
4 | - | - | - | - |
|
S82906-2mg买3赠1 |
99.00% | ￥280.00 |
6 | - | - | - | - |
|
S82906-5mg买3赠1 |
99.00% | ￥540.00 |
5 | - | - | - | - |
|
S82906-10mg买3赠1 |
99.00% | ￥892.00 |
6 | - | - | - | - |
|
S82906-25mg买3赠1 |
99.00% | ￥1650.00 |
5 | - | - | - | - |
|
S82906-50mg买3赠1 |
99.00% | ￥2500.00 |
5 | - | - | - | - |
|
S82906-100mg买3赠1 |
99.00% | ￥3300.00 |
3 | - | - | - | - |
|
| 产品描述： | PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Human CCR2:5.2 nM (IC50);Mouse CCR2:13 nM (IC50);Rat CCR2:17 nM (IC50);CCR | ||||||||||||||||||||
| 体内研究： | PF-4136309 (2 mg/kg) exhibits a moderate half-life in both species after iv administration (2.5 and 2.4 h). When administered orally, PF-4136309 (10 mg/kg) is absorbed rapidly, with peak concentration time (Tmax) at 1.2 h for rats and 0.25 h for dogs. A similar half-life is observed in both species between iv dosing and po dosing. PF-4136309 is well absorbed, with an oral bioavailability of 78% in both species | ||||||||||||||||||||
| 参考文献： | 1. Xue CB, et al. Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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