货号	规格	价格	上海	北京	珠海	重庆	武汉
S82920-1mg买3赠1	99.60%	￥160.00 S82920-1mg ￥160.00 现货（买3赠1）	4 4	-	-	-	-
S82920-2mg买3赠1	99.60%	￥220.00 S82920-2mg ￥220.00 现货（买3赠1）	7 7	-	-	-	-
S82920-5mg买3赠1	99.60%	￥300.00 S82920-5mg ￥300.00 现货（买3赠1）	6 6	-	-	-	-
S82920-10mg买3赠1	99.60%	￥490.00 S82920-10mg ￥490.00 现货（买3赠1）	4 4	-	-	-	-
S82920-25mg买3赠1	99.60%	￥1150.00 S82920-25mg ￥1150.00 现货（买3赠1）	5 5	-	-	-	-
S82920-50mg买3赠1	≥99%	￥2000.00 S82920-50mg ￥2000.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S82920-100mg	≥99%	￥2900.00 S82920-100mg ￥2900.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.

靶点：

IC50: 100 nM (p97);p97

体外研究：

ML240 is a potent p97 inhibitor, with an IC50 of 100 nM. ML240 is active in the UbG76V-GFP stabilization assay (IC50, 0.9 μM). ML240 inhibits p97 competitively with respect to ATP with a Ki values of 0.22 μM. ML240 also inhibits labeling of only three protein kinase domains by >50% when tested at 20 μM: PIP5 K3 (belongs to phosphoinositide-3 kinase family), JAK1 JH2 (N-terminal pseudokinase domain of JAK1), and DNAPK (DNA-dependent protein kinase). ML240 (1.1, 3.3, 10, or 20 μM) induces executioner caspases 3 and 7 and triggers cell death independently of apical caspases 8 and 9. ML240 is cytotoxic to HCT15 and SW403 cells, with GI50s of 0.76 and 0.5 μM after treatment for 24 h, and 0.54 and 0.5 μM after treatment for 72 h, respectively

参考文献：

1. Chou TF et al. Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem, 2013 Feb, 8(2):297-312. 2. Chou TF, et al. Selective, reversible inhibitors of the AAA ATPase p97. Probe Reports from the NIH Molecular Libraries Program. April 14, 2011.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.522 ml	12.612 ml	25.224 ml
5 mM	0.504 ml	2.522 ml	5.045 ml
10 mM	0.252 ml	1.261 ml	2.522 ml
50 mM	0.05 ml	0.252 ml	0.504 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置