货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
S82928-5mg	≥95%	￥660.00 S82928-5mg ￥660.00 3-5天	0 货期：3-5天	-	-	-	-
S82928-10mg	≥95%	￥1070.00 S82928-10mg ￥1070.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

S82928-5mg

≥95%

￥660.00

货期：3-5天

S82928-10mg

≥95%

￥1070.00

货期：3-5天

产品描述：

YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific BCRP inhibitor

靶点：

Epigenetic Reader Domain;EpigeneticReaderDomain

体外研究：

YHO-13177 enhances SN-38, mitoxantrone and topotecan in BCRP transduced human colon cancer HCT116 (HCT116/BCRP) cells and BCRP-expressing SN-38 resistant human lung cancer A549 (A549/SN4) Cytotoxicity in cells, but little effect on parental cells. In addition, YHO-13177 potentiates the cytotoxicity of SN-38 in human lung cancer NCI-H460 and NCI-H23, myeloma RPMI-8226, and pancreatic cancer AsPC-1 cells that intrinsically expressed BCRP. YHO-13177 increases the intracellular accumulation of Hoechst 33342, a substrate of BCRP, at 30 minutes and partially suppresses the expression of BCRP protein at more than 24 hours after its treatment in both HCT116/BCRP and A549/SN4 cells .

体内研究：

YHO-13351 was rapidly converted into YHO-13177 after its oral or intravenous administration In mice. Coadministration of irinotecan with YHO-13351 significantly increased the survival time of mice inoculated with BCRP-transduced murine leukemia P388 cells and suppressed the tumor growth in an HCT116/BCRP xenograft model, whereas irinotecan alone had little effect in these tumor models

参考文献：

1. Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.725 ml	8.625 ml	17.249 ml
5 mM	0.345 ml	1.725 ml	3.45 ml
10 mM	0.172 ml	0.862 ml	1.725 ml
50 mM	0.034 ml	0.172 ml	0.345 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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