| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82970-1mg买3赠1 |
99.70% | ￥360.00 |
8 | - | - | - | - |
|
S82970-2mg买3赠1 |
99.70% | ￥690.00 |
8 | - | - | - | - |
|
S82970-5mg买3赠1 |
99.70% | ￥930.00 |
8 | - | - | - | - |
|
S82970-10mg促销 |
99.70% | ￥1500.00 ￥1200.00 |
5 | - | - | - | - |
|
S82970-25mg促销 |
99.70% | ￥2160.00 ￥1720.00 |
5 | - | - | - | - |
|
S82970-50mg促销 |
99.70% | ￥2920.00 ￥2330.00 |
4 | - | - | - | - |
|
S82970-100mg促销 |
≥98% | ￥4120.00 ￥3290.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | HG-14-10-04 is a potent ALK and mutant EGFR inhibitor with IC50s of 20 nM, 15.6 nM, 22.6 nM and 124.5 nM for ALK, EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS, respectively. HG-14-10-04 can be used to research anticancer | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | EGFRLR/TM：15.6 nM (IC50)；EGFR19del/TM/CS：22.6 nM (IC50)；EGFRLR/TM/CS：124.5 nM (IC50)；ALK：20 nM (IC50);ALK | ||||||||||||||||||||
| 体外研究： | HG-14-10-04 (example 10) has inhibitory activity against ALK kinase with an IC50 of 20 nM HG-14-10-04 (compound 17b) exhibits kinase inhibitory activity against EGFRLR/TM, EGFR19del/TM/CS and EGFRLR/TM/CS with IC50s of 15.6 nM, 22.6 nM and 124.5 nM, respectively | ||||||||||||||||||||
| 参考文献： | 1. U.S. Pat. Appl. Publ. (2012), US 20120028924 A1 2. Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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