| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S82991-1mg买3赠1 |
99.90% | ￥100.00 |
>10 | - | - | - | - |
|
S82991-2mg买3赠1 |
99.90% | ￥150.00 |
>10 | - | - | - | - |
|
S82991-5mg买3赠1 |
99.90% | ￥220.00 |
>10 | - | - | - | - |
|
S82991-10mg买3赠1 |
99.90% | ￥310.00 |
9 | - | - | - | - |
|
S82991-25mg买3赠1 |
99.90% | ￥520.00 |
8 | - | - | - | - |
|
S82991-50mg |
99.90% | ￥800.00 |
6 | - | - | - | - |
|
S82991-100mg |
99.90% | ￥1400.00 |
3 | - | - | - | - |
|
| 产品描述： | TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively. | ||||||||||||||||||||
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| 靶点： | Ki: 5 nm(Pim-1), 239 nM (Pim-2), 42 nM (Pim-3);Pim | ||||||||||||||||||||
| 体外研究： | TP-3654 demonstrates potent PIM-1 specific cellular activity in the PIM-1/BAD overexpression system with an average EC50 of 67 nM. TP-3654 treatment reduces levels of phospho-BAD in vitro using the bladder cancer cell line UM-UC-3. TP-3654 reduces colony growth of T24 and UM-UC3 cells, confirming the PIM-1–dependent growth for both cell lines | ||||||||||||||||||||
| 体内研究： | Oral dosing of 200 mg/kg TP-3654 significantly reduces both UM-UC-3 and PC-3 tumor growth measured by volume (caliper) and by final tumor weight, with no significant changes in body weight or gross adverse toxicity | ||||||||||||||||||||
| 参考文献： | 1. Foulks JM, et al. A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas. Neoplasia. 2014 May;16(5):403-12. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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