| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83010-2mg买3赠1 |
99.90% | ￥180.00 |
5 | - | - | - | - |
|
S83010-5mg买3赠1 |
99.90% | ￥290.00 |
5 | - | - | - | - |
|
S83010-10mg买3赠1 |
99.90% | ￥380.00 |
6 | - | - | - | - |
|
S83010-25mg促销 |
99.90% | ￥800.00 ￥640.00 |
3 | - | - | - | - |
|
S83010-50mg促销 |
99.90% | ￥1230.00 ￥984.00 |
3 | - | - | - | - |
|
S83010-100mg促销 |
99.90% | ￥2070.00 ￥1650.00 |
2 | - | - | - | - |
|
S83010-200mg促销 |
≥98% | ￥3800.00 ￥3040.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | RG14620 is an EGFR inhibitor with an IC50 of 3 μM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | EGFR:3 μM (IC50, Cell Assay);EGFR; HER | ||||||||||||||||||||
| 体外研究： | RG14620 inhibits colony formation (IC50=3 μM) and DNA synthesis (IC50=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC50=4 μM) and DNA synthesis (IC50=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible | ||||||||||||||||||||
| 体内研究： | RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals | ||||||||||||||||||||
| 参考文献： | 1. Sagara Y, et al. Tyrphostins protect neuronal cells from oxidative stress. J Biol Chem. 2002 Sep 27;277(39):36204-15. 2. Yoneda T, et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51(16):4430-5. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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