货号	规格	价格	上海	北京	珠海	重庆	武汉
S83032-5mg	≥98%	￥520.00 S83032-5mg ￥520.00 3-5天	0 货期：3-5天	-	-	-	-
S83032-10mg	≥98%	￥710.00 S83032-10mg ￥710.00 3-5天	0 货期：3-5天	-	-	-	-
S83032-25mg	≥98%	￥1260.00 S83032-25mg ￥1260.00 3-5天	0 货期：3-5天	-	-	-	-
S83032-50mg	≥98%	￥1830.00 S83032-50mg ￥1830.00 3-5天	0 货期：3-5天	-	-	-	-

大包装询价收藏产品

加入购物车

到货通知，提交手机号入库后将短信通知。

产品描述：

IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.

靶点：

pKi: 7.85 (OX2R), 6.29 (OX1R);OXReceptor

体外研究：

Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. IPSU binds rapidly and reaches equilibrium very quickly in binding and/or functional assays

体内研究：

IPSU has low blood clearance, shows high maximal blood exposure and AUC after oral dosing. It exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration. IPSU increases sleep when dosed during the mouse active phase (lights off); IPSU induces sleep primarily by increasing NREM sleep. IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing. The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day

参考文献：

1. Betschart C, et al. Identification of a novel series of orexin receptor antagonists with a distinct effect on sleeparchitecture for the treatment of insomnia. J Med Chem. 2013 Oct 10;56(19):7590-607. 2. Callander GE, et al. Kinetic properties of 'dual' orexin receptor antagonists at OX1R and OX2R orexin receptors. Front Neurosci. 2013 Dec 3;7:230. 3. Hoyer D, et al. Distinct effects of IPSU and suvorexant on mouse sleep architecture. Front Neurosci. 2013 Dec 10;7:235.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.466 ml	12.331 ml	24.661 ml
5 mM	0.493 ml	2.466 ml	4.932 ml
10 mM	0.247 ml	1.233 ml	2.466 ml
50 mM	0.049 ml	0.247 ml	0.493 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置