货号	规格	价格	上海	北京	珠海	重庆	武汉
S83035-2mg买3赠1	99.10%	￥260.00 S83035-2mg ￥260.00 现货（买3赠1）	7 7	-	-	-	-
S83035-5mg买3赠1	99.10%	￥360.00 S83035-5mg ￥360.00 现货（买3赠1）	7 7	-	-	-	-
S83035-10mg买3赠1	99.10%	￥670.00 S83035-10mg ￥670.00 现货（买3赠1）	1 1	-	-	-	-
S83035-25mg买3赠1	99.10%	￥1490.00 S83035-25mg ￥1490.00 现货（买3赠1）	4 4	-	-	-	-
S83035-50mg买3赠1	99.10%	￥2650.00 S83035-50mg ￥2650.00 现货（买3赠1）	4 4	-	-	-	-
S83035-100mg买3赠1	99.10%	￥4170.00 S83035-100mg ￥4170.00 现货（买3赠1）	2 2	-	-	-	-
S83035-300mg	99.10%	￥11000.00 S83035-300mg ￥11000.00 现货	1 1	-	-	-	-

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产品描述：

TUG-891是一种有效的、选择性 long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120) 激动剂

靶点：

FFA4/GPR120;GPR

体外研究：

TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4 across various assay end points, including stimulation of Ca²⁺ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor

体内研究：

TUG-891 acutely increases fat oxidation and reduces body weight and fat mass in C57Bl/6J mice by activating GPR120

细胞实验：

Cell lines: Human FFA4-eYFP Flp-In T-REx cells, HT-29 cells Concentrations: 10 μM Incubation Time: 1.5 min, 5 min, 45 min Method: Intracellular Ca2+ is monitored for 1.5 min after TUG-891 treatment, and the measured response is taken as the peak signal over this time course. Extracellular signal-regulated kinase 1/2 (ERK) phosphorylation is examined in Flp-In T-REx cell lines, or in HT-29 cells after 5 minutes of TUG-891 treatment. For visualization of FFA4 Internalization, human FFA4-eYFP Flp-In T-REx cells are cultured on poly-d-lysine coated glass coverslips and cultured for 24 hours before treatment with doxycycline (100 ng/ml) to induce receptor expression. Live cells are imaged after TUG-891 addition using a confocal microscopy system.

参考文献：

1. Hudson BD, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol. 2013 Nov;84(5):710-25. 2. Schilperoort M, et al. The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. EMBO Mol Med. 2018 Mar;10(3):e8047.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.744 ml	13.721 ml	27.442 ml
5 mM	0.549 ml	2.744 ml	5.488 ml
10 mM	0.274 ml	1.372 ml	2.744 ml
50 mM	0.055 ml	0.274 ml	0.549 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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