| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83048-1mg买3赠1 |
99.90% | ￥120.00 |
8 | - | - | - | - |
|
S83048-2mg买3赠1 |
99.90% | ￥150.00 |
7 | - | - | - | - |
|
S83048-5mg促销 |
99.90% | ￥235.00 ￥188.00 |
7 | - | - | - | - |
|
S83048-10mg促销 |
99.90% | ￥325.00 ￥260.00 |
6 | - | - | - | - |
|
S83048-25mg促销 |
99.90% | ￥560.00 ￥448.00 |
5 | - | - | - | - |
|
S83048-50mg促销 |
≥98% | ￥890.00 ￥712.00 |
货期：2-3天 | - | - | - | - |
|
S83048-100mg |
≥98% | ￥1490.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | PBTZ169 inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043. | ||||||||||||||||||||
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| 靶点： | Antibacterial;DprE1;Antibacterial; DprE1 | ||||||||||||||||||||
| 体外研究： | PBTZ169, inhibit decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1) and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. | ||||||||||||||||||||
| 体内研究： | PBTZ169 can be suspend in 0.25% hydroxy-propylmethyl-cellulose. The administertration for PBTZ169 is 100 mg/kg by gavage. The MIC50 and MIC90 values were 0.0075 and 0.030 μg/mL, respectively. The MIC for PBTZ169 for N. brasiliensis HUJEG-1 was 0.0037 μg/mL. PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB). | ||||||||||||||||||||
| 参考文献： | 1. Makarov V,et al. The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52. 2. González-Martínez NA,et al. In Vivo Activity of the Benzothiazinones PBTZ169 and BTZ043 against Nocardia brasiliensis. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京