| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83061-1mg买3赠1 |
99.80% | ￥290.00 |
6 | - | - | - | - |
|
S83061-2mg买3赠1 |
99.80% | ￥390.00 |
7 | - | - | - | - |
|
S83061-5mg买3赠1 |
99.80% | ￥490.00 |
6 | - | - | - | - |
|
S83061-10mg买3赠1 |
99.80% | ￥740.00 |
6 | - | - | - | - |
|
S83061-25mg促销 |
99.80% | ￥1330.00 ￥1060.00 |
5 | - | - | - | - |
|
S83061-50mg促销 |
≥98% | ￥2100.00 ￥1680.00 |
货期：2-3天 | - | - | - | - |
|
S83061-100mg促销 |
≥98% | ￥3800.00 ￥3040.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates | ||||||||||||||||||||
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| 靶点： | Potassium Channel;PotassiumChannel | ||||||||||||||||||||
| 体外研究： | GAL-021 is being developed as a novel breathing control modulator to preserve respiratory drive and protect patients from respiratory impairment due to opioids and other modalities. Using inside-out patches in GH3 cells, GAL-021 exerts concentration-dependent inhibition of single-channel KCa1.1 activity. When evaluated against 12 different cardiac ion channels, inhibition is 35% or less at 30 μM. No significant kinase inhibition is observed at 10 μM. At 30 μM in the radioligand binding assays, interactions (defined as >50% radioligand displacement) are detected at adenosine A1 (65% I), A2A (79% I, IC50 approximately 5μM), and A3 (93% I; IC50 approximately 1 μM) receptors, at 5-HT2B receptors (60% I; IC50 approximately 30 μM) | ||||||||||||||||||||
| 体内研究： | Intravenously administered GAL-021 attenuates opiate-induced respiratory depression in rats and nonhuman primates without affecting analgesia in rats. GAL-021 ventilatory stimulation in rats is attenuated by carotid sinus nerve transection. GAL-021 ventilatory stimulation is attenuated in mice lacking the pore-forming α-subunit of the KCa 1.1 channel | ||||||||||||||||||||
| 参考文献： | 1. Golder FJ, et al. Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator. Anesthesiology. 2015 Nov;123(5):1093-104. 2. J F McLeod, et al. GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers. Br J Anaesth. 2014 Nov;113(5):875-83. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京