货号	规格	价格	上海	北京	珠海	重庆	武汉
S83069-5mg买3赠1	≥98%	￥340.00 S83069-5mg ￥340.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S83069-10mg买3赠1	98.10%	￥432.00 S83069-10mg ￥432.00 现货（买3赠1）	4 4	-	-	-	-
S83069-25mg买3赠1	98.10%	￥952.00 S83069-25mg ￥952.00 现货（买3赠1）	8 8	-	-	-	-
S83069-100mg买3赠1	98.10%	￥1760.00 S83069-100mg ￥1760.00 现货（买3赠1）	1 1	-	-	-	-

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产品描述：

BD-1047 (dihydrobromide) is a selective functional antagonist of sigma-1 receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia

靶点：

sigma-1 receptor;Sigmareceptor

体外研究：

BD-1047 (dihydrobromide) prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells.
BD-1047 (dihydrobromide) attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity.

体内研究：

BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice. BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine). BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity. Animal Model: Male Albino Swiss mice (50 days old, 25–28 g) Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg Administration: Intraperitoneal injection Result: Decreased the APO-induced climbing at the dose of 10 mg/kg in mice.

参考文献：

1. Skuza G, et al. Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity. Pharmacol Rep. 2006 Sep-Oct;58(5):626-635. 2. Shimazawa M, et al. Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage. Exp Eye Res. 2015 Mar;132:64-72. 3. Rogóz Z, et al. Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats. Pharmacol Rep. 2006 Jul-Aug;58(4):493-500.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.288 ml	11.441 ml	22.881 ml
5 mM	0.458 ml	2.288 ml	4.576 ml
10 mM	0.229 ml	1.144 ml	2.288 ml
50 mM	0.046 ml	0.229 ml	0.458 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

BD1047 HBr

BD-1047 (dihydrobromide)

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)