货号	规格	价格	上海	北京	珠海	重庆	武汉
S83071-5mg买3赠1	99.10%	￥680.00 S83071-5mg ￥680.00 现货（买3赠1）	6 6	-	-	-	-
S83071-10mg促销	99.10%	￥1050.00 ￥840.00 S83071-10mg ￥840.00 现货	5 5	-	-	-	-
S83071-25mg促销	99.10%	￥2080.00 ￥1660.00 S83071-25mg ￥1660.00 现货	5 5	-	-	-	-
S83071-100mg促销	≥98%	￥4500.00 ￥3600.00 S83071-100mg ￥3600.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.

靶点：

HIF;HIF/HIFProlyl-Hydroxylase; HIF

体外研究：

SYP-5 inhibits hypoxia-induced upregulation of HIF-1. SYP-5 inhibits HIF-1 and downstream gene expression in Hep3B and Bcap37 cells. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. The proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, are down-regulated by SYP-5. SYP-5 displays significant inhibition on hypoxia-induced overexpression of VEGF and MMP2 in both cell lines. In the tube formation assay, SYP-5 suppresses angiogenesis induced by hypoxia and VEGF in vitro. SYP-5 also retards the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS. SYP-5 specifically inhibits hypoxic induction of luciferase expression in U251-HRE but not in U251-pGL3

参考文献：

1. Wang LH, et al. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur J Pharmacol. 2016 Nov 15;791:560-568.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.201 ml	16.006 ml	32.012 ml
5 mM	0.64 ml	3.201 ml	6.402 ml
10 mM	0.32 ml	1.601 ml	3.201 ml
50 mM	0.064 ml	0.32 ml	0.64 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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