货号	规格	价格	上海	北京	珠海	重庆	武汉
S83085-1mg买3赠1	99.60%	￥206.00 S83085-1mg ￥206.00 现货（买3赠1）	5 5	-	-	-	-
S83085-5mg促销	99.60%	￥644.00 ￥642.00 S83085-5mg ￥642.00 现货	7 7	2	-	-	-
S83085-10mg促销	99.60%	￥976.00 ￥975.00 S83085-10mg ￥975.00 现货	6 6	-	-	-	-
S83085-25mg买3赠1	99.60%	￥1040.00 S83085-25mg ￥1040.00 现货（买3赠1）	6 6	-	-	-	-
S83085-50mg买3赠1	99.60%	￥1540.00 S83085-50mg ￥1540.00 现货（买3赠1）	5 5	-	-	-	-
S83085-100mg买3赠1	99.60%	￥2060.00 S83085-100mg ￥2060.00 现货（买3赠1）	4 4	-	-	-	-

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产品描述：

Lys05 (Lys01 trihydrochloride) is a novel lysosomal autophagy inhibitor with IC50 values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.

靶点：

IC50: 3.6 μM (1205Lu), 3.8 μM (c8161), 6 μM (LN229), 7.9 μM (HT-29);lysosomalautophagy; Autophagy

体外研究：

Lys01, is a 10-fold more potent autophagy inhibitor than HCQ. Compared with HCQ, Lys05, a water-soluble salt of Lys01, more potently accumulates within and deacidifies the lysosome. Lys01 and Lys05 produce equivalent dose-dependent increases in the LC3II/LC3I ratio, accumulation of the autophagy cargo protein p62, and identical IC50 values in the MTT assay

体内研究：

With this high-dose, short-term treatment, no mice die, but after 2 d of dosing, mice treated with Lys05 76 mg/kg i.p. are observed to have arched backs and lethargy. Morphologically, EM show that cells with intact nuclear and cytoplasmic membranes contain large AVs in Lys05-treated tumors. Tumor growth is significantly impaired in Lys05-treated tumors compared with controls. Lys05 treatment results in a 53% reduction in the average daily tumor growth rate compared with vehicle-treated controls. A significant three- and six-fold accumulation of AV is observed at the end of 14 d of treatment in HCQ- and Lys05-treated tumors, respectively, compared with control-treated tumors

参考文献：

1. McAfee Q, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.819 ml	9.095 ml	18.19 ml
5 mM	0.364 ml	1.819 ml	3.638 ml
10 mM	0.182 ml	0.91 ml	1.819 ml
50 mM	0.036 ml	0.182 ml	0.364 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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Lys01 (trihydrochloride)