| 产品描述: | N-563 is an analogue of deoxyspergualin with an immunostimulating activity,it promotes resistance to Candida albicans infection in mice. In vivo: The protective effect of the N-563 against C. albicans infection was investigated in normal and immunosuppressed mice. In normal mice, N-563 treatment at 10 mg/kg for 3 days prior to infection significantly prolonged the survival time. In immunosuppressed mice treated with a single dose of cyclophosphamide 4 days prior to infection, N-563 at 3 and 10 mg/kg for 3 days prior to infection also significantly prolonged the survival time of mice. In addition, it augmented the phagocytic activity of neutrophils and enhanced the delayed type hypersensitivity reaction against C. albicans. Coincidentally, N-563 appeared to protect against secondary infection with C. albicans in the delayed type hypersensitivity-positive mice. N-563 was dissolved in physiological saline and filtered through a Millipore filter (0.22μm). |
| 靶点: |
Fungal;Others |
| 参考文献: |
1. Aoyagi K. et al.The novel immunostimulant N-563, an analogue of deoxyspergualin, promotes resistance to Candida albicans infection in mice.The Journal of Antibiotics.Oct;47(10):1077-83.doi:10.7164/antibiotics.47.1077(1994) |
| 溶解性: |
Soluble in DMSO |
| 保存条件: |
2-8℃ |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.782 ml |
13.911 ml |
27.823 ml |
| 5 mM |
0.556 ml |
2.782 ml |
5.565 ml |
| 10 mM |
0.278 ml |
1.391 ml |
2.782 ml |
| 50 mM |
0.056 ml |
0.278 ml |
0.556 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |