货号	规格	价格	上海	北京	珠海	重庆	武汉
S83166-10mg	≥99%	￥630.00 S83166-10mg ￥630.00 3-5天	0 货期：3-5天	-	-	-	-
S83166-50mg	≥99%	￥1830.00 S83166-50mg ￥1830.00 3-5天	0 货期：3-5天	-	-	-	-
S83166-100mg	≥99%	￥2830.00 S83166-100mg ￥2830.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.

靶点：

sPLA2:2.5 nM (Ki);5-HT2A Receptor:0.06 nM (Ki);5-HT2C Receptor:0.03 nM (Ki);5-HT7 Receptor:0.13 nM (Ki);D2 Receptor:1.3 nM (Ki);D3 Receptor:0.42 nM (Ki);D4 Receptor:1.1 nM (Ki);Others

体外研究：

Relative to its D2 receptor affinity, Asenapine has a higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B and D3 receptors, suggesting stronger engagement of these targets at therapeutic doses. Asenapine behaves as a potent antagonist (pKB) at 5-HT1A (7.4), 5-HT1B (8.1), 5-HT2A (9.0), 5-HT2B (9.3), 5-HT2C (9.0), 5-HT6 (8.0), 5-HT7 (8.5), D2 (9.1), D3 (9.1), α2A (7.3), α2B (8.3), α2C (6.8) and H1 (8.4) receptors

体内研究：

Asenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Asenapine may have superior therapeutic effect on anxiety symptoms than other agents in rats. Asenapine has anxiolytic-like effects in the EPM and the defensive marble burying tests in mice

参考文献：

1. Stoner SC, Pace HA. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34(5):1023-40. 2. Shahid M, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23(1):65-73. 3. Ohyama M,et al. Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model. Acta Neuropsychiatr. 2016 Dec;28(6):327-336. 4. Ene HM, et al. Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice. Acta Neuropsychiatr. 2016 Apr;28(2):85-91.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.103 ml	15.517 ml	31.034 ml
5 mM	0.621 ml	3.103 ml	6.207 ml
10 mM	0.31 ml	1.552 ml	3.103 ml
50 mM	0.062 ml	0.31 ml	0.621 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

Asenapine (hydrochloride)