| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83207-1mg |
≥98% | ￥290.00 |
货期：3-5天 | - | - | - | - |
|
S83207-2mg |
≥98% | ￥530.00 |
货期：3-5天 | - | - | - | - |
|
S83207-5mg |
≥98% | ￥900.00 |
货期：3-5天 | - | - | - | - |
|
S83207-10mg |
≥98% | ￥1230.00 |
货期：3-5天 | - | - | - | - |
|
S83207-25mg |
≥98% | ￥2140.00 |
货期：3-5天 | - | - | - | - |
|
S83207-50mg |
≥98% | ￥3130.00 |
货期：3-5天 | - | - | - | - |
|
| 产品描述： | TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors | ||||||||||||||||||||
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| 靶点： | EP2;5-HTReceptor; ProstaglandinReceptor | ||||||||||||||||||||
| 体外研究： | TG6-10-1 robustly blocks prostaglandin E2 (PGE2) (10 μM)-induced cAMP accumulation in a concentration-dependent manner in SH-SY5Y cells | ||||||||||||||||||||
| 体内研究： | TG6-10-1 (5 mg/kg; i.p.; 4-30 hours) improves survival, accelerates recovery of lost weight, and improves functional recovery following status epilepticus (SE). Animal Model: C57BL/6 mice (pilocarpine-induced SE) Dosage: 5 mg/kg Administration: Intraperitoneal injection; 4, 21, 30 hours Result: A significant increase in survival and accelerating the recovery of lost weight in post-SE mice. | ||||||||||||||||||||
| 参考文献： | 1. Jiang J, et al. Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3591-3596. 2. Kang X, et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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