货号	规格	价格	上海	北京	珠海	重庆	武汉
S83242-2mg买3赠1	99.60%	￥20.00 S83242-2mg ￥20.00 现货（买3赠1）	1957 >10	-	-	-	-
S83242-5mg买3赠1	99.60%	￥40.00 S83242-5mg ￥40.00 现货（买3赠1）	787 >10	-	-	-	-
S83242-10mg买3赠1	99.60%	￥70.00 S83242-10mg ￥70.00 现货（买3赠1）	407 >10	-	-	-	-
S83242-25mg买3赠1	99.60%	￥120.00 S83242-25mg ￥120.00 现货（买3赠1）	164 >10	-	-	-	-
S83242-50mg买3赠1	99.60%	￥200.00 S83242-50mg ￥200.00 现货（买3赠1）	87 >10	-	-	-	-
S83242-100mg买3赠1	99.60%	￥270.00 S83242-100mg ￥270.00 现货（买3赠1）	49 >10	-	-	-	-

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产品描述：

Osimertinib mesylate (AZD9291) 是osimertinib的甲磺酸盐形式，是口服的第三代 epidermal growth factor receptor (EGFR) 酪氨酸激酶(TKI)抑制剂

靶点：

EGFR

体外研究：

Osimertinib-resistant lung adenocarcinoma (LUAD) cells express higher level of METTL7B in comparison to Osimertinib-sensitive cells. Knock-down of METTL7B by GNC-siRNA re-sensitized LUAD cells to osimertinib

体内研究：

METTL7B is significantly increased in both mRNA and protein level in osimertinib -resistant xenografts as compared with those in osimertinib-sensitive xenografts. In LUAD CDX mouse model, combination treatment with GNC-siMETTL7B (6 mg siRNA per mouse equivalent) significantly suppresses tumor growth as compared with treatment of osimertinib (30 mg/kg) alone.

细胞实验：

Cell lines: lung adenocarcinoma (LUAD) cell lines Concentrations: 0.001 -1 µM Incubation Time: 72 h Method: Cells are plated at a density of 3,000 cells/well in 96 well plates. Osimertinib is added to the medium and treated for 72 h. Cell viability assays are performed by Cell Counting Kit-8.

参考文献：

1. Song H, et al. Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma. Mol Cancer. 2022 Feb 10;21(1):43. 2. Alessandro Leonetti, et al. Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer. Br J Cancer . 2019 Oct;121(9):725-737.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.679 ml	8.393 ml	16.787 ml
5 mM	0.336 ml	1.679 ml	3.357 ml
10 mM	0.168 ml	0.839 ml	1.679 ml
50 mM	0.034 ml	0.168 ml	0.336 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

AZD-9291 (mesylate)