| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83244-1mg买3赠1 |
99.00% | ￥240.00 |
6 | - | - | - | - |
|
S83244-2mg买3赠1 |
99.00% | ￥408.00 |
7 | - | - | - | - |
|
S83244-5mg买3赠1 |
99.00% | ￥490.00 |
6 | - | - | - | - |
|
S83244-10mg买3赠1 |
99.00% | ￥780.00 |
6 | - | - | - | - |
|
S83244-25mg促销 |
99.00% | ￥1580.00 ￥1260.00 |
5 | - | - | - | - |
|
S83244-50mg促销 |
≥98% | ￥2540.00 ￥2030.00 |
货期：2-3天 | - | - | - | - |
|
S83244-100mg促销 |
≥98% | ￥4050.00 ￥3240.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | ML-18 is a non-peptide bombesin receptor subtype-3 (BRS-3) antagonist with an IC50 of 4.8 μM. | ||||||||||||||||||||
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| 靶点： | IC50: 4.8 μM (BRS-3);BombesinReceptor | ||||||||||||||||||||
| 体外研究： | ML-18 inhibits specific 125I-BA1 (DTyr-Gln-Trp-Ala-Val-βAla-His-Phe-Nle-NH2)BB6-14 binding to NCI-H1299 lung cancer cells stably transfected with BRS-3 with IC50 values of 4.8 μM. ML-18 binds with lower affinity to the GRPR and NMBR with IC50 values of 16 and more than 100 μM, respectively. ML-18 at 16 μM inhibits the ability of 10 nM BA1 to elevate cytosolic Ca2+ in a reversible manner using lung cancer cells loaded with FURA2-AM. ML-18 at 16 μM inhibits the ability of 100 nM BA1 to cause tyrosine phosphorylation of the EGFR and ERK in lung cancer cells. It inhibits the proliferation of lung cancer cells | ||||||||||||||||||||
| 参考文献： | 1. Moody TW, et al. ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides. 2015 Feb;64:55-61. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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