货号	规格	价格	上海	北京	珠海	重庆	武汉
S83247-1mg	≥98%	￥420.00 S83247-1mg ￥420.00 3-5天	0 货期：3-5天	-	-	-	-
S83247-5mg	≥98%	￥990.00 S83247-5mg ￥990.00 3-5天	0 货期：3-5天	-	-	-	-
S83247-10mg	≥98%	￥1560.00 S83247-10mg ￥1560.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.

靶点：

RIP2 Kinase;RIPkinase

体外研究：

GSK2983559 active metabolite is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase, which is also referred to as CARD3, RICK, CARDIAK, or RIPK2, is a TKL family serine/threonine protein kinase involved in innate immune signaling. RIP2 kinase is composed of an N-terminal kinase domain and a C-terminal caspase-recruitment domain (CARD) linked via an intermediate (IM) region. The CARD domain of RIP2 kinase mediates interaction with other CARD-containing proteins, such as NODI and NOD2. NODI and NOD2 are cytoplasmic receptors which play a key role in innate immune surveillance. They recognize both gram positive and gram negative bacterial pathogens and are activated by specific peptidoglycan motifs, diaminopimelic acid (i.e., DAP) and muramyl dipeptide

参考文献：

1. Linda N. Casillas, et al. Prodrugs of amino quinazoline kinase inhibitor. PCT Int. Appl. (2014), WO 2014043446 A1 20140320.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.181 ml	10.904 ml	21.808 ml
5 mM	0.436 ml	2.181 ml	4.362 ml
10 mM	0.218 ml	1.09 ml	2.181 ml
50 mM	0.044 ml	0.218 ml	0.436 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

RIP2 kinase inhibitor 1