| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83262-1mg买3赠1 |
99.00% | ￥100.00 |
5 | - | - | - | - |
|
S83262-2mg买3赠1 |
99.00% | ￥140.00 |
5 | - | - | - | - |
|
S83262-5mg |
99.00% | ￥170.00 |
5 | - | - | - | - |
|
S83262-10mg |
99.00% | ￥270.00 |
5 | - | - | - | - |
|
S83262-50mg |
99.00% | ￥880.00 |
2 | - | - | - | - |
|
S83262-100mg |
≥98% | ￥1490.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy. | ||||||||||||||||||||
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| 靶点： | Influenza Virus;InfluenzaVirus | ||||||||||||||||||||
| 体外研究： | KIN1148 induces the dose-dependent nuclear translocation of IRF3 in PH5CH8 cells and specific activation of IRF3- responsive promoters. KIN1148 also elicits greater induction of endogenous IRF3-dependent ISG54 and OASL expression by PH5CH8 cells | ||||||||||||||||||||
| 体内研究： | Prime-boost immunization of mice with a suboptimal dose of a monovalent pandemic influenza split virus H1N1 A/California/07/2009 vaccine plus KIN1148 protect against a lethal challenge with mouse-adapted influenza virus (A/California/04/2009) and induce an influenza virusspecific IL-10 and Th2 response by T cells derived from lung and lung-draining lymph nodes. Primeboost immunization with vaccine plus KIN1148, but not prime immunization alone, induce antibodies capable of inhibiting influenza virus hemagglutinin and neutralizing viral infectivity. Nevertheless, a single immunization with vaccine plus KIN1148 provide increased protection over vaccine alone and reduce viral load in the lungs after challenge | ||||||||||||||||||||
| 参考文献： | 1. Probst P, et al. A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response. Vaccine. 2017 Apr 4;35(15):1964-1971. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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