货号	规格	价格	上海	北京	珠海	重庆	武汉
S83308-1mg买3赠1	99.10%	￥160.00 S83308-1mg ￥160.00 现货（买3赠1）	1008 >10	-	-	-	-
S83308-5mg买3赠1	99.10%	￥230.00 S83308-5mg ￥230.00 现货（买3赠1）	207 >10	-	-	-	-
S83308-10mg买3赠1	99.10%	￥350.00 S83308-10mg ￥350.00 现货（买3赠1）	105 >10	-	-	-	-
S83308-25mg买3赠1	99.10%	￥640.00 S83308-25mg ￥640.00 现货（买3赠1）	45 >10	-	-	-	-
S83308-50mg买3赠1	99.10%	￥1030.00 S83308-50mg ￥1030.00 现货（买3赠1）	28 >10	-	-	-	-
S83308-100mg买3赠1	99.10%	￥2010.00 S83308-100mg ￥2010.00 现货（买3赠1）	11 >10	-	-	-	-

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产品描述：

Firsocostat (GS-0976, NDI-010976, ND-630)是acetyl CoA carboxylase (ACC)的一种可逆抑制剂，对hACC1和hACC2的IC50分别为2.1 nM，6.1 nM

靶点：

hACC1(Cell-free assay):2.1 nM; hACC2(Cell-free assay):6.1 nM;Acetyl-CoACarboxylase

体外研究：

When ND-630 and [14C]acetate were administered to Hep-G2 cells for 4 h, ND-630 inhibited FASyn with EC50 values of 66 nM in cells cultured in medium containing. When ND-630 and[14C]palmitate were administered to C2C12 cells for 6 h, ND-630 increased both the release of [14C]O2 and the production of[14C]acid-soluble material

体内研究：

When administered chronically to rats with diet-induced obesity, ND-630 reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia

细胞实验：

Cell lines: HepG2 cells Concentrations: 2.1 nM (ACC1); 6.1 nM (ACC2) Incubation Time: 1 h Method: Cells were treated with varying concentrations of ND-630.

动物实验：

Animal Models: Male Sprague–Dawley rats Dosages: 10 mg/kg Administration: o.g.

参考文献：

1. Harriman G,et al. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc Natl Acad Sci U S A.2016 29;113(13):E1796-805.

溶解性：

Soluble in DMSO、Ethanol

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.756 ml	8.778 ml	17.555 ml
5 mM	0.351 ml	1.756 ml	3.511 ml
10 mM	0.176 ml	0.878 ml	1.756 ml
50 mM	0.035 ml	0.176 ml	0.351 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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